Riestenberg C, Kroener L, Quinn M, Ching K, Ambartsumyan G. What is the clinical impact of the endometrial receptivity array in PGT-A and oocyte donation cycles? J Assist Reprod Genet. Neves AR, Devesa M, Martínez F, Garcia-Martinez S, Rodriguez I, Polyzos NP, Coroleu B. Understanding and improving endometrial receptivity. Miravet-Valenciano JA, Rincon-Bertolin A, Vilella F, Simon C. Profiling the gene signature of endometrial receptivity: clinical results. Garrido-Gómez T, Ruiz-Alonso M, Blesa D, Diaz-Gimeno P, Vilella F, Simón C. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. 2018 Jul 35(7):1301-1305 ( view)ĭíaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alamá P, Pellicer A, Simón C. Does the endometrial receptivity array really provide personalized embryo transfer? J Assist Reprod Genet. Should the endometrium be receptive, the frozen embryo transfer (FET) will be planned for the next cycle, exactly on the same day the endometrial biopsy was performed.īassil R, Casper R, Samara N, Hsieh TB, Barzilay E, Orvieto R, Haas J. This makes it necessary to freeze the embryos obtained during the IVF cycle until the transfer is carried out. Processing the sample and obtaining the results may take a few days, so the implantation window period of the same cycle would be lost. Whether or not the endometrial receptivity test shows a receptive result, the embryo transfer should be postponed until at least the next cycle. In this case it would be necessary to repeat the test on another day of the menstrual cycle until finding the location of the implantation window. Non-receptive the endometrial sample is not expressing the receptivity genes, so the implantation window does not corresponds to the day the biopsy was performed. That moment of the cycle is optimal to perform the embryo transfer and it would not be necessary to repeat the ERA Test. Once the endometrial sample has been analyzed by genetic comparison, the result of the ERA test can be as follows: Receptive the endometrial sample is expressing the receptivity genes, so the implantation window corresponds to the day the biopsy was performed. Join our inviTRA community Follow us ERA test results Thanks to scientific and technological advances in the field of genetics, it has been possible to identify the expression of certain key genes for an endometrium to reach the receptive state.Īmong the many genes analyzed, the expression of 248 genes has been found to be vital for qualifying an endometrium as receptive. Therefore, molecular tools such as the ERA test have been developed to obtain more reliable results. However, the determination of endometrial receptivity by direct observation of the tissue may not be entirely accurate. Cell growth endometrial thickening is caused by a massive increase in endometrial cells. Glands the presence of glands in the endometrial tissue is characteristic of the period of receptivity. Presence of pinopods these are cytoplasmic projections that arise from endometrial cells. These characteristic details that denote that the endometrium is in a state of receptivity are as follows: Endometrial thickening the endometrium measures between 7 and 10 mm when it is receptive. The characteristics that differentiate a receptive from a non-receptive endometrium can be identified by ultrasound or by analyzing the tissue itself under the microscope. However, in a substituted cycle where the woman is taking hormonal medication for endometrial preparation, the biopsy will be performed 5 days after starting the administration of progesterone, i.e. When to perform endometrial biopsy for ERA Lesbian Artificial Insemination by Donor.Fertility Treatments for Lesbian Couples.Fertility Treatments for Single Mothers.What is Assisted Reproductive Technology?.
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